Topical Finasteride

What does the research say?

Research on topical finasteride has shown promising results. A phase III clinical trial found that topical finasteride 0.25% significantly increased hair count compared to placebo, with an adjusted mean change of 20.2 hairs versus 6.7 hairs at 24 weeks [2] . Another study suggested that topical finasteride may be as effective as oral finasteride but with fewer systemic side effects [11] . However, more research is needed to determine the optimal concentration, frequency, and long-term efficacy of topical finasteride.

Pruritus (itching)

Pruritus, or itching, is a common side effect of topical finasteride, often occurring at the application site [2] [11] .

Erythema (redness)

Erythema, or redness, may develop on the scalp due to irritation from the topical solution [2] [11] .

Loss of or reduction in libido

Some individuals may experience a loss of or reduction in libido, although this is less common with topical finasteride compared to oral finasteride [2] [11] .

Scalp irritation

Scalp irritation, including burning or stinging sensations, can occur after applying topical finasteride [2] [11] .

Contact dermatitis

Contact dermatitis, characterized by inflammation and itching, may develop in some users as a reaction to the topical solution [2] [11] .

[1] Androgenetic Alopecia: Therapy Update.

This review discusses the use of microneedling and minoxidil for treating androgenetic alopecia (AGA). Microneedling promotes hair growth by releasing growth factors, while minoxidil increases vascular endothelial growth factor (VEGF) and prolongs the anagen phase of hair growth.

[2] Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial.

This phase III clinical trial evaluated the efficacy and safety of topical finasteride 0.25% in men with androgenetic alopecia. The study found that topical finasteride significantly improved hair count compared to placebo, with fewer systemic side effects than oral finasteride.

[3] Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.

This review discusses various treatment options for androgenetic alopecia, including platelet-rich plasma (PRP), which promotes hair growth by releasing growth factors and improving hair density.

[4] Natural products for male androgenetic alopecia.

This article reviews the potential of natural products, such as saw palmetto and rosemary oil, as alternative treatments for male androgenetic alopecia, particularly for patients skeptical of conventional treatments like minoxidil and finasteride.

[5] Female-pattern hair loss: therapeutic update.

This review discusses the use of topical finasteride and minoxidil for female-pattern hair loss (FPHL). Minoxidil is a first-line treatment, while finasteride, though off-label, has shown efficacy in improving hair density in women.

[6] Finasteride for hair loss: a review.

This review discusses the use of finasteride 1 mg/day for treating male androgenetic alopecia, highlighting its efficacy in reducing dihydrotestosterone (DHT) levels and promoting hair growth.

[7] New Treatments for Hair Loss.

This review summarizes new treatments for hair loss, including topical finasteride, low-level laser therapy, and regenerative medicine, highlighting their potential efficacy and safety.

[8] Male Androgenetic Alopecia

This review discusses the pathophysiology and treatment options for male androgenetic alopecia, including topical minoxidil and oral finasteride, and their efficacy in preventing hair loss and promoting regrowth.

[9] Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review.

This systematic review evaluates the efficacy of topical ketoconazole in treating androgenetic alopecia, suggesting it as a promising adjunctive or alternative therapy.

[10] Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs.

This review discusses the use of platelet-rich plasma (PRP) for treating androgenetic alopecia, highlighting its ability to promote hair growth and improve hair density.

[11] Topical Finasteride: A Comprehensive Review of Androgenetic Alopecia Management for Men and Women.

This review provides a comprehensive overview of topical finasteride as a treatment for androgenetic alopecia, emphasizing its potential to minimize systemic side effects while promoting hair regrowth.

[12] What's New in Therapy for Male Androgenetic Alopecia?

This review discusses emerging treatments for male androgenetic alopecia, including topical finasteride, oral minoxidil, and platelet-rich plasma, highlighting their efficacy and safety.

[13] Hirsutism in Women.

This review discusses the causes and treatments of hirsutism in women, including the use of finasteride and other pharmacologic agents.