Overview
What is it?
Topical adapalene is a synthetic retinoid, a derivative of vitamin A, that is applied directly to the skin. It is FDA-approved for the treatment of acne vulgaris, a common skin condition that affects many people, especially adolescents and young adults. Adapalene is not naturally occurring but is specifically designed to target acne at its source.
How does it work?
Topical adapalene works by normalizing the growth of skin cells and reducing inflammation. It helps to unclog pores by preventing the formation of microcomedones, which are the early stages of acne lesions. Additionally, it has anti-inflammatory properties that help reduce redness and swelling associated with acne .
What are the benefits?
Topical adapalene is effective in treating both inflammatory and non-inflammatory acne lesions. It helps to prevent new acne from forming and can reduce the appearance of existing acne. When used consistently, it can also help prevent acne scarring. Adapalene is often used in combination with other treatments like benzoyl peroxide for enhanced efficacy .
Effectiveness
What does the research say?
Research shows that topical adapalene is a first-line treatment for mild to moderate acne. Studies have demonstrated its effectiveness in reducing acne lesions, with improvements typically seen within 6 to 8 weeks of consistent use. It is also well-tolerated by most patients, making it a popular choice for long-term acne management .
Side Effects
Skin irritation
Skin irritation is common, especially during the initial weeks of use, but usually subsides as the skin adjusts .
Dryness
Dryness may occur, particularly in areas where the product is applied. Using a non-comedogenic moisturizer can help alleviate this .
Redness
Redness is a temporary side effect that typically resolves with continued use .
Peeling
Peeling of the skin may happen as the medication works to unclog pores and renew the skin .
Burning or stinging sensation
A burning or stinging sensation may occur, especially if the skin is sensitive. Starting with alternate-day application can help minimize this .
Evidence
Clinical Studies & Trials
[1] Guidelines of care for the management of acne vulgaris.
This paper provides guidelines for managing acne vulgaris, a common skin condition affecting adolescents and adults.
View study[2] Management of Acne Vulgaris: A Review.
This review discusses the global prevalence of acne vulgaris and its impact on quality of life, as well as treatment options.
View study[3] Managing acne vulgaris: an update.
This review highlights the use of topical antibiotics, retinoids (including adapalene), and benzoyl peroxide as first-line treatments for mild to moderate acne.
View study[4] Novel and emerging treatment options for acne vulgaris.
This paper reviews emerging treatments for acne, including new formulations of existing compounds like adapalene.
View study[5] Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.
This meta-analysis compares the effectiveness of various topical treatments for acne, including azelaic acid and benzoyl peroxide.
View study[6] Topical Retinoids in Acne Vulgaris: A Systematic Review.
This systematic review highlights the role of topical retinoids, including adapalene, as first-line treatments for acne vulgaris.
View study[7] Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations.
This review discusses the use of retinoids, including adapalene, in both acne treatment and anti-aging applications.
View study[8] Adapalene
This paper provides an overview of adapalene, its FDA-approved uses for acne, and its off-label applications.
View study