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Comprehensive acne treatment comparison based on clinical studies and research data

Treatment	Effectiveness	Side Effects	Evidence
Oral Isotretinoin	10.0	Severe	Conclusive
Topical Antibiotic and Retinoid and Benzoyl Peroxide	7.9	Moderate	Conclusive
Oral Antibiotic and Topical Retinoid and Benzoyl Peroxide	7.2	Significant	Strong
Topical Antibiotic and Second Generation Retinoid	6.8	Moderate	Moderate
Topical Antibiotic and Azelaic Acid	6.7	Minor	Moderate
Topical Retinoid and Benzoyl Peroxide	5.9	Moderate	Conclusive
Oral Antibiotic and Topical Retinoid	5.8	Significant	Strong
Topical Clindamycin and Benzoyl Peroxide	5.6	Minor	Conclusive
Ethinyl Estradiol and Chlormadinone Acetate	5.4	Significant	Strong
Topical Antibiotic and First Generation Retinoid	5.3	Moderate	Moderate
Topical Isotretinoin	4.5	Minor	Emerging
Benzoyl Peroxide Topical	4.3	Minimal	Conclusive
Ethinyl Estradiol and Drospirenone	4.3	Moderate	Strong
Ethinyl Estradiol and Cyproterone Acetate	4.2	Significant	Strong
Topical Tazarotene	4.0	Moderate	Strong
Topical Erythromycin and Zinc	3.9	Moderate	Moderate
Topical Adapalene	3.9	Minimal	Conclusive
Ethinyl Estradiol and Norgestimate	3.8	Moderate	Moderate
Topical Erythromycin and Benzoyl Peroxide	3.8	Minor	Strong
Topical Tretinoin	3.7	Minor	Conclusive
Topical Nadifloxacin and Benzoyl Peroxide	3.4	Minor	Moderate
Topical Clascoterone	3.4	Minimal	Moderate
Oral Doxycycline	3.3	Significant	Strong
Oral Lymecycline	3.2	Significant	Strong
Oral Minocycline	3.0	Severe	Moderate
Topical Trifarotene	2.9	Minor	Strong
Azelaic Acid Topical	2.9	Minimal	Strong
Oral Azithromycin	2.7	Significant	Moderate
Topical Erythromycin	2.7	Moderate	Emerging
Topical Clindamycin	2.7	Moderate	Emerging
Ethinyl Estradiol and Levonorgestrel	2.1	Moderate	Emerging
Oral Tetracycline	2.0	Significant	Moderate
Topical Minocycline	1.9	Minor	Moderate
Oral Sarecycline	1.7	Moderate	Strong
Ethinyl Estradiol and Desogestrel	1.6	Moderate	Moderate
Topical Nadifloxacin	0.7	Minor	Emerging

This content delivers research-informed educational resources, not medical guidance. Always consult a qualified healthcare provider before initiating any treatment, supplement, or health program. Individual results will vary.

Unlock Clear Skin

Comprehensive acne treatment comparison based on clinical studies and research data

Oral Isotretinoin

Topical Antibiotic and Retinoid and Benzoyl Peroxide

Oral Antibiotic and Topical Retinoid and Benzoyl Peroxide

Topical Antibiotic and Second Generation Retinoid

Topical Antibiotic and Azelaic Acid

Topical Retinoid and Benzoyl Peroxide

Oral Antibiotic and Topical Retinoid

Topical Clindamycin and Benzoyl Peroxide

Ethinyl Estradiol and Chlormadinone Acetate

Topical Antibiotic and First Generation Retinoid

Topical Isotretinoin

Benzoyl Peroxide Topical

Ethinyl Estradiol and Drospirenone

Ethinyl Estradiol and Cyproterone Acetate

Topical Tazarotene

Topical Erythromycin and Zinc

Topical Adapalene

Ethinyl Estradiol and Norgestimate

Topical Erythromycin and Benzoyl Peroxide

Topical Tretinoin

Topical Nadifloxacin and Benzoyl Peroxide

Topical Clascoterone

Oral Doxycycline

Oral Lymecycline

Oral Minocycline

Topical Trifarotene

Azelaic Acid Topical

Oral Azithromycin

Topical Erythromycin

Topical Clindamycin

Ethinyl Estradiol and Levonorgestrel

Oral Tetracycline

Topical Minocycline

Oral Sarecycline

Ethinyl Estradiol and Desogestrel

Topical Nadifloxacin