Overview
What is it?
Topical trifarotene is a synthetic retinoid, specifically a selective retinoic acid receptor gamma (RAR-γ) agonist, used for the treatment of acne. It is not naturally occurring but is designed to target acne effectively by regulating skin cell turnover and reducing inflammation.
How does it work?
Topical trifarotene works by binding to retinoic acid receptors (RARs), particularly the RAR-gamma isoform, which plays a key role in acne development. It helps normalize skin cell turnover, reduces clogged pores (comedones), and has anti-inflammatory properties, making it effective in treating both inflammatory and non-inflammatory acne lesions .
What are the benefits?
Topical trifarotene is effective in reducing both inflammatory (red, swollen pimples) and non-inflammatory (blackheads and whiteheads) acne lesions on the face and trunk. Studies have shown significant improvements over 12 weeks, with continued benefits observed up to 52 weeks of use. In clinical trials, 57.9% of patients achieved clear or almost clear skin on both the face and trunk after one year of treatment .
Effectiveness
What does the research say?
Research supports the efficacy of topical trifarotene for acne treatment. In two phase III trials (PERFECT 1 and PERFECT 2), trifarotene applied once daily significantly reduced acne lesions compared to a placebo. Long-term studies showed that 57.9% of patients achieved clear or almost clear skin on the face and trunk after 52 weeks of treatment .
Side Effects
Transient local irritation
Mild irritation at the application site, which usually resolves over time .
Erythema (redness)
Redness of the skin, often temporary and mild .
Scaling
Flaking or peeling of the skin, which can be managed with moisturizers .
Dryness
Dryness of the skin, a common side effect of retinoids .
Burning sensation
A mild burning sensation upon application, typically short-lived .
Sunburn
Increased sensitivity to sunlight, leading to sunburn if proper sun protection is not used .
Allergic dermatitis
A rare but possible allergic reaction, requiring discontinuation of use .
Evidence
Clinical Studies & Trials
[1] Guidelines of care for the management of acne vulgaris.
This paper provides guidelines for managing acne vulgaris, a common skin condition affecting adolescents and adults.
View study[2] Trifarotene for acne.
This study evaluates the efficacy and safety of trifarotene, a selective RAR-gamma agonist, for treating acne. It highlights improvements in acne lesions over 12 weeks and long-term benefits up to 52 weeks.
View study[3] Management of Acne Vulgaris With Trifarotene.
This study discusses the use of trifarotene in managing acne vulgaris, focusing on its efficacy and safety profile.
View study[4] New Developments in Topical Acne Therapy.
This review highlights recent advancements in topical acne treatments, including trifarotene, and discusses their improved tolerability and efficacy.
View study[5] Novel and emerging treatment options for acne vulgaris.
This paper reviews emerging acne treatments, including trifarotene, and their mechanisms of action, efficacy, and tolerability.
View study[6] New Acne Therapies and Updates on Use of Spironolactone and Isotretinoin: A Narrative Review.
This review discusses new acne therapies, including trifarotene, and compares their efficacy and side effects with existing treatments.
View study[7] Update: Mechanisms of Topical Retinoids in Acne.
This paper explores the mechanisms of topical retinoids, including trifarotene, in treating acne, focusing on their effects on skin cell regulation and inflammation.
View study[8] Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis.
This review discusses the role of trifarotene in acne treatment, emphasizing its ability to regulate keratinization and its high efficacy and tolerability.
View study