Overview
What is it?
Topical erythromycin is an antibiotic used to treat acne. It is not naturally occurring and is derived from the bacterium Saccharopolyspora erythraea. It is applied directly to the skin to reduce acne-causing bacteria and inflammation.
How does it work?
Topical erythromycin works by targeting and reducing the population of Cutibacterium acnes (C. acnes), a bacteria that contributes to acne. It also has anti-inflammatory properties, helping to reduce redness and swelling associated with acne lesions .
What are the benefits?
Topical erythromycin is effective in treating inflammatory acne, such as papules and pustules. It is considered safe for use during pregnancy and lactation, making it a suitable option for women of childbearing age. Additionally, it can be combined with other treatments like benzoyl peroxide to enhance its effectiveness and reduce the risk of antibiotic resistance .
Effectiveness
What does the research say?
Research shows that topical erythromycin is effective in reducing inflammatory acne lesions. It is often used in combination with other treatments, such as benzoyl peroxide, to improve outcomes and minimize the risk of bacterial resistance. Studies have demonstrated its safety and efficacy, particularly in pregnant and lactating women .
Side Effects
Skin irritation
Skin irritation, such as redness or itching, may occur at the application site .
Dryness
Dryness of the skin is a common side effect, especially with prolonged use .
Burning sensation
A burning sensation may be experienced, particularly when first starting treatment .
Antibiotic resistance
Prolonged use of topical erythromycin can lead to antibiotic resistance, which is why it is often combined with benzoyl peroxide .
Mild gastrointestinal effects (if applied to the nipple during breastfeeding)
If applied to the nipple during breastfeeding, it may cause mild gastrointestinal effects in the infant, such as diarrhea .
Evidence
Clinical Studies & Trials
[1] Guidelines of care for the management of acne vulgaris.
This paper provides guidelines for managing acne vulgaris, emphasizing the use of topical treatments like erythromycin for inflammatory acne.
View study[2] Guidelines of care for the management of acne vulgaris.
This evidence-based guideline reviews the management of acne, including the use of topical antibiotics like erythromycin.
View study[3] Management of Acne in Pregnancy.
This review discusses the safety and efficacy of topical erythromycin for treating acne during pregnancy.
View study[4] Treatment of Acne in Pregnancy.
This paper outlines the safety profile of topical erythromycin for acne treatment during pregnancy.
View study[5] Acne vulgaris.
This review discusses the use of topical antibiotics like erythromycin and their effectiveness in treating acne.
View study[6] Erythromycin
This paper reviews the safety of erythromycin during breastfeeding and its use as a topical treatment for acne.
View study[7] Acne vulgaris.
This review discusses the benefits and side effects of topical erythromycin in treating acne.
View study