Stress Management

What does the research say?

Research shows that stress management techniques, such as massage therapy, can significantly reduce cortisol levels by up to 31% and increase serotonin and dopamine levels by 28% and 31%, respectively, promoting relaxation and reducing stress [12] . Antioxidants and NAD+ precursors have been shown to improve cellular function, reduce oxidative damage, and potentially extend lifespan in preclinical studies [9] [11] . While the exact years of life expectancy gained are not quantified, the overall impact on health and well-being suggests a meaningful contribution to longevity.

Limited evidence on long-term effects of NAD+ precursors

Long-term effects of NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are not fully understood, and more research is needed to confirm their safety over extended periods [11] .

Potential for toxic metabolite accumulation

Raising NAD+ levels may lead to the accumulation of toxic metabolites, which could have adverse effects on cellular health [11] .

Risk of tumorigenesis with NAD+ therapy

There is a theoretical risk that increasing NAD+ levels could promote tumorigenesis or cellular senescence, although this has not been conclusively proven in human studies [11] .

Patient-specific reactions to antioxidants

Antioxidants and other stress management supplements may cause varying reactions depending on individual health conditions, requiring a tailored approach to minimize risks [9] .

[1] Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures

This paper discusses the diagnosis and treatment of chronic lymphocytic leukemia (CLL), a common type of leukemia in elderly patients, highlighting the role of genomic alterations in disease progression.

[2] Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia

This paper provides consensus guidelines for the diagnosis and treatment of T-cell prolymphocytic leukemia (T-PLL), emphasizing the need for standardized criteria in clinical trials.

[3] Global guideline for the diagnosis and management of rare mould infections

This guideline provides recommendations for the diagnosis and management of rare mould infections, emphasizing the importance of a multidisciplinary approach.

[4] iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL

This paper updates the guidelines for the diagnosis and treatment of chronic lymphocytic leukemia (CLL), incorporating new genetic tests and targeted therapies.

[5] The Aging Cardiovascular System: Understanding It at the Cellular and Clinical Levels

This review explores the mechanisms of cardiovascular aging and potential strategies to mitigate age-related cardiovascular diseases.

[6] Transition to Practice for New Nurse Graduates: Barriers and Mitigating Strategies

This paper examines the challenges faced by new nurse graduates and strategies to reduce stress and improve retention in the healthcare workforce.

[7] Developmental Programming of Fetal Growth and Development

This paper discusses how maternal stress can affect fetal development and lead to long-term health consequences, emphasizing the importance of stress management during pregnancy.

[8] Resveratrol (RV): A pharmacological review and call for further research

This review highlights the health benefits of resveratrol, including its antioxidant, anti-inflammatory, and anti-aging properties, and calls for further research into its therapeutic potential.

[9] Ovarian Aging: Molecular Mechanisms and Medical Management

This paper discusses the role of oxidative stress in ovarian aging and explores treatments like antioxidants and melatonin to slow down ovarian decay and improve fertility.

[10] Sarcopenia: Etiology, Nutritional Approaches, and miRNAs

This review explores the causes of sarcopenia and the role of nutrition and microRNAs in managing age-related muscle loss.

[11] NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis

This paper evaluates the potential benefits and risks of NAD+ therapy for age-related degenerative diseases, highlighting its role in energy production and cellular repair.

[12] Cortisol decreases and serotonin and dopamine increase following massage therapy

This review highlights the positive effects of massage therapy on reducing cortisol levels and increasing serotonin and dopamine, which help alleviate stress and improve well-being.

[13] Hormesis determines lifespan

This paper discusses the concept of hormesis and its role in extending lifespan through activities like exercise and physical activity, though it does not provide specific numerical values for lifespan extension.

[14] Frailty in Critical Care Medicine: A Review

This review examines the impact of frailty in critical care settings and discusses strategies to manage stress and improve outcomes for elderly patients.

[15] Glucotoxicity: potential mechanisms

This paper explores the mechanisms of glucotoxicity and its impact on aging, highlighting the role of hyperglycemia in premature aging and tissue damage.